MovDisordV3, Main, Exploration, bibRecord, 001083

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Identifieur interne : 001083 ( Main/Exploration ); précédent : 001082; suivant : 001084

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Auteurs : Alexander Storch [Allemagne] ; Ilona Csoti [Allemagne] ; Karla Eggert [Allemagne] ; Tove Henriksen [Danemark] ; Annika Plate [Allemagne] ; Michael Lorrain [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Angelo Antonini [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423956

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Atrophie multisystématisée, Pathologie du système nerveux, Intrarachidien, Système autologue, Moelle osseuse, Préparation, Cellule souche, Stroma, Transplantation.
Wicri :
- topic : Cellule souche.

English descriptors

KwdEn :
- Autologous system, Bone marrow, Intrathecal, Multiple system atrophy, Nervous system diseases, Parkinson disease, Preparation, Stem cell, Stroma, Transplantation.

Abstract

Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.

Affiliations:

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Le document en format XML

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<author><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name>
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<author><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name>
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<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
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<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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<s2>Venice</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Venice</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes</title>
<author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
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<author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1>
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<author><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospital of Bispebjerg</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>4 aut.</sZ>
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<author><name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Ludwig Maximillians University</s1>
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</affiliation>
</author>
<author><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Neurological Practice Düsseldorf</s1>
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<s3>DEU</s3>
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</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
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<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo</s1>
<s2>Venice</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Venice</wicri:noRegion>
</affiliation>
</author>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autologous system</term>
<term>Bone marrow</term>
<term>Intrathecal</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Preparation</term>
<term>Stem cell</term>
<term>Stroma</term>
<term>Transplantation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Atrophie multisystématisée</term>
<term>Pathologie du   système nerveux</term>
<term>Intrarachidien</term>
<term>Système autologue</term>
<term>Moelle osseuse</term>
<term>Préparation</term>
<term>Cellule souche</term>
<term>Stroma</term>
<term>Transplantation</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Danemark</li>
<li>Italie</li>
</country>
<region><li>Bavière</li>
<li>District de Dresde</li>
<li>District de Giessen</li>
<li>District de Haute-Bavière</li>
<li>Hesse (Land)</li>
<li>Hovedstaden</li>
<li>Saxe (Land)</li>
</region>
<settlement><li>Copenhague</li>
<li>Dresde</li>
<li>Marbourg</li>
<li>Munich</li>
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<tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
</region>
<name sortKey="Csoti, Ilona" sort="Csoti, Ilona" uniqKey="Csoti I" first="Ilona" last="Csoti">Ilona Csoti</name>
<name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name>
<name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name>
<name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name>
<name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
<name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri